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Meaning:
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something that blocks a way, prevents progress

obstacle, impediment

blockage hindrance interference bar barricade barrier block blocking check checkmate circumvention difficulty gridlock hamper hurdle jam lock mountain restraint roadblock snag stop stoppage trammel trouble wall booby trap monkey wrench stumbling block
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Cases of word usage

1) causing, likely or intended to cause, obstruction (obstructive)

2) to remove an obstruction from (a drain etc) (unblock)

OBSTRUCTION as in Wiktionary
OBSTRUCTION as in Wikipedia