great mental suffering

severe upset or pain

in a state of being desperate

hopelessness

(a cause of) great pain, discomfort or sorrow

pain, agony

deep or great sorrow

mental suffering

the state of being very unhappy; great suffering (of mind or body); great misfortune

pain, mental or physical

the feeling of being sorry or unhappy at the loss of something; a disappointment or a sad event

upset over past action

unhappiness, depression

unhappiness, depression

(a cause of) sadness or regret

extreme upset, grief

(a cause of) trouble, grief

pain, unhappiness

(an example of) worry; unhappiness; difficulty; a nuisance; (an) illness

annoyance, worry

sorrow

sorrow

suffering

suffering

great sadness; causes of woe; troubles

suffering

(something that causes) the state feeling anxious or troubled

anxiety, trouble