(a cause of) great pain, discomfort or sorrow
pain, agony
Cases of word usage
1) to make a deep sound forced out by pain, despair or distress (groan)
2) causing distress (harrowing)
3) extremely harmful, causing distress (pernicious)
4) to annoy, cause distress in, (a person) (vex)
5) to show pain or distress by a movement, sound or by loss of control (wince)
