great pain or anxiety

suffering, pain

great mental suffering

severe upset or pain

the state of being depressed; a hollow place in the surface of something, especially the ground

low spirits; despair

(a cause of) great pain, discomfort or sorrow

pain, agony

semi-darkness

melancholy, depression

deep or great sorrow

mental suffering

the state of being very unhappy; great suffering (of mind or body); great misfortune

pain, mental or physical

strong, enthusiastic feeling especially of love, hate or anger

strong emotion

unhappiness, depression

unhappiness, depression

(a cause of) sadness or regret

extreme upset, grief

the causing of mental or physical suffering, especially to get information; (a) pain caused or suffered

severe mental or physical pain

(an example of) a form of drama in which there is conflict and suffering and a sad ending; (an instance of) a very sad event, experience etc in real life

disaster