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Meaning:
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the state of being depressed; a hollow place in the surface of something, especially the ground

low spirits; despair

abasement abjection blahs bleakness bummer cheerlessness dejection desolation desperation despondency discouragement dispiritedness distress dole dolefulness dolor downheartedness dreariness dullness dumps ennui gloom gloominess heavyheartedness hopelessness lowness melancholia melancholy misery mortification qualm sadness sorrow trouble unhappiness vapors woefulness worry abjectness blue funk disconsolation heaviness of heart lugubriosity the blues
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Cases of word usage

1) a mental depression due to unnecessary anxiety about one's health (hypochondriac)

2) unhappiness, depression (sadness)

DEPRESSION as in Wiktionary
DEPRESSION as in Wikipedia