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Meaning:
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a person, insect, thing, act etc that causes trouble or offence

annoyance; annoying person

blister bore bother botheration bum creep drag drip exasperation frump gadfly headache inconvenience infliction insect irritant irritation louse nag nudge offense pain pest pesterer pill plague problem terror trouble vexation besetment botherment pain in the neck pester poor excuse
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Cases of word usage

1) a troublesome or destructive thing, animal etc; a child who is a nuisance (pest)

NUISANCE as in Wiktionary
NUISANCE as in Wikipedia