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History
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1) trouble; irritation (hassle)

2) a feeling of irritation on the skin, causing a desire to scratch (itch)

Synonyms
UK
US
Meaning:
anger

the strong feeling that comes after being insulted, wrong or because of cruelty and Injustice (and make a person wants to quarrel or fight)

state of being mad, annoyed

annoyance

the state of being annoyed

feeling of being irritated

bother

a person, thing, that causes trouble, worry or annoyance

trouble, inconvenience

displeasure

the state of feeling annoyed, angry or offended

unhappiness, anger

dissatisfaction

the state of being dissatisfied

discontent, unhappiness

distress

(a cause of) great pain, discomfort or sorrow

pain, agony

friction

the rubbing of one thing against another; (an instance of) a difference of opinion leading to argument and quarrelling

rubbing

goad

to encourage, urge a person, especially to do wrong

stimulus

inflammation

(an example, instance of) an inflamed condition (especially of some part of the body)

redness, swelling

itch

a feeling of irritation on the skin, causing a desire to scratch

scratching; tingling

nuisance

a person, insect, thing, act etc that causes trouble or offence

annoyance; annoying person

pain

the feeling of physical suffering or hurt

physical suffering

pains

trouble; effort

physical suffering

pest

a troublesome or destructive thing, animal etc; a child who is a nuisance

person or thing that presents problem

rage

(an outburst of) extreme or violent anger

extreme anger

shame

the sad feeling with loss of self-respect, caused by wrong, dishonourable or foolish behaviour, failure etc (of oneself, one's family etc)

disgrace, embarrassment

tizzy

to be in a nervous state

anger

torment

(something that causes) severe bodily or mental pain or suffering

severe mental distress

tormentor

a person who torments

person or thing that presents problem

trouble

(an example of) worry; unhappiness; difficulty; a nuisance; (an) illness

annoyance, worry

unrest

disturbed social condition(s)

state of agitation; disturbance

worry

(something that causes) the state feeling anxious or troubled

anxiety, trouble

wrath

great anger (especially caused by injustice)

extreme anger

IRRITATION as in Wiktionary
IRRITATION as in Wikipedia