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Meaning:
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(an instance of) bad luck (which is more usual)

disaster

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Cases of word usage

1) a big and serious misfortune or disaster (e.g. an earthquake or flood) (calamity)

2) (a) large or sudden misfortune (e.g. a flood or fire, an earthquake, a serious defeat in war, the loss of a large sum of money) (disaster)

3) the state of being very unhappy; great suffering (of mind or body); great misfortune (misery)

MISFORTUNE as in Wiktionary
MISFORTUNE as in Wikipedia