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1) to feel contempt for (a person); consider (a person) to be worthless (despise)

2) bits of worthless matter which sink to the bottom of liquid in a glass, bottle, barrel etc (dregs)

3) worthless because small; of no importance (paltry)

4) waste or worthless objects, materials etc (to be burnt etc); to say 'no' to (a request or offer); to show unwillingness to accept, do, (something) (refuse)

5) worthless material or writing; rubbish; refuse; worthless people (trash)

Synonyms
UK
US
Meaning:
abject

cool, miserable

hopeless and downtrodden

abortive

unsuccessful

failing to achieve a goal

base

(of a person, behaviour, thought) dishonourable; immoral

vulgar, low

contemptible

deserving or causing contempt

despicable, shameful

crummy

inferior in quality

lousy

despicable

deserving to be despised

hateful; beyond contempt

futile

(of an action) of no use; having no effect

hopeless, pointless

grotty

dirty; unpleasant; bad

lousy

inane

silly

stupid

inconsequential

unimportant

insignificant

ineffective

not producing the effect(s) desired

useless

invertebrate

(of) an animal without a backbone or spinal column, e.g. insects, worms

weak, useless

measly

of little value; of poor quality; of small size or amount

skimpy

naught

nothing

zero

naughty

(of children, behaviour etc) bad; wrong (but usually not seriously)

bad, misbehaved

null

not valid

ineffectual, valueless

pathetic

causing pity; weak and useless

sad, affecting

pitiable

pitiful

pitiful

pitiful

feeling, showing, pity

in bad shape; poor

pointless

with little or no sense, aim or purpose

ridiculous, senseless

puny

small and weak

small, insignificant

scrapper

not working; not valuable

not working; not valuable

shrimp

a kind of small shellfish with many legs and a long tail, used as food

small, insignificant

subnormal

below normal (especially intelligence)

deficient, inadequate

trivial

of little value or importance; ordinary (and so dull)

not important

unavailing

without effect or success

futile

unimportant

not important

of no real worth, value

unnecessary

not necessary; that could have been avoided

not required

unproductive

not productive

idle, non-productive

useless

having no use; not able to do what is intended; having no result

not working; not valuable

vicious

given or done with evil or cruel intent

corrupt, wrong

vile

shameful and disgusting; very bad

offensive, horrible

wicked

(of a person, behaviour) wrong; immoral; very bad; mischievous

corrupt, bad

wretched

very bad, sad etc; of poor quality

terrible, very bad

zipper

zip

of no real worth, value

WORTHLESS as in Wiktionary
WORTHLESS as in Wikipedia