something that adds new difficulties (e.g. of a person who is ill)

difficult situation

the state of being mixed up, disordered

disorientation

a turning point in an illness, life, history

critical situation

to win a victory over (a player, team, rival)

overthrow, beating

a situation in which one has to choose between two things, two courses of action etc

crisis

the absence of comfort

irritation, pain

(a cause of) great pain, discomfort or sorrow

pain, agony

(of something organized) a complete failure

catastrophe

to be in / get into a dilemma, an awkward situation; a position found, e.g. when sailing, by taking bearings, observing the stars etc

difficult or ticklish situation

an amount of a drug that is too much

excess

to be in a state of doubt or confusion

delicate situation

a question, statement or description, intended to make a person think hard in order to know the answer or meaning; to make many holes in a person, thing

brain-teaser

a complete defeat and disorderly retreat

overwhelming defeat

to make (something) clean, smooth or level by pushing a hard edge of a tool, something rough etc along the surface

bad or embarrassing situation

a narrow passage of water connecting two seas; trouble; difficulty

crisis, difficulty