(an instance of) bad luck, trouble

bad luck, situation

fear and uncertainty about the future

worry, tension

not pleasant or enjoyable

poor quality

(a kind of) drug used to calm a person's nerves and to cause sleep

soothing agent, medicine

a person who people find uninteresting and tiring

nuisance

the state of being disappointed

saddening situation; let-down

the feeling of strong fear and discouragement

disappointed feeling; distress

to be sad, depressed

depression

unhappiness, depression

unhappiness, depression

a serious fall (in prices etc); a period when business is bad; (of a person) to sit down, fall, heavily

decline, failure

(an example of) a form of drama in which there is conflict and suffering and a sad ending; (an instance of) a very sad event, experience etc in real life

disaster

a drug that produced a calm mental state

soothing agent, medicine

(a cause of) trouble, grief

pain, unhappiness