Cases of word usage

1) a person who has tried (a career etc) but failed to do well (also-ran)

2) to break (something) to pieces; make (something) useless; put an end to (hopes, a career etc) (destroy)

3) advice or help on educational, personal, career etc matters (guidance)

4) (of a person) likely to succeed in a profession, career etc (up-and-coming)