(to make) a great effort, fight
hard try; fight to win
Cases of word usage
1) a struggle (fight)
2) to hold and struggle with; to try to deal with (a problem etc) (grapple)
3) (the belief in) the main theory of Karl Marx (1818 - 1883) that social and political changes are caused by a struggle between social classes and that socialism will eventually replace capitalism (marxism)
4) (to take part in) a rough fight or struggle (scuffle)
5) involved in a struggle etc (throes)
6) (to have) a difficult fight or struggle (tussle)
7) to struggle (with a person) and try to throw her or him to the ground (wrestle)