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Meaning:
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(to make) a great effort, fight

hard try; fight to win

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Cases of word usage

1) a struggle (fight)

2) to hold and struggle with; to try to deal with (a problem etc) (grapple)

3) (the belief in) the main theory of Karl Marx (1818 - 1883) that social and political changes are caused by a struggle between social classes and that socialism will eventually replace capitalism (marxism)

4) (to take part in) a rough fight or struggle (scuffle)

5) involved in a struggle etc (throes)

6) (to have) a difficult fight or struggle (tussle)

7) to struggle (with a person) and try to throw her or him to the ground (wrestle)

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STRUGGLE as in Wikipedia