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Meaning:
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(an instance of) an act of refusing

denial of responsibility; unwillingness

ban defiance exclusion noncompliance rejection reversal veto abnegation choice declension declination disapproval disavowal disclaimer disfavor dissent enjoinment forbidding interdiction negation nix no nonacceptance option pass prohibition proscription rebuff refutation regrets renouncement renunciation repudiation repulse repulsion turndown withholding writ cold shoulder disallowance discountenancing knockback nonconsent thumbs down
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Cases of word usage

1) an obvious refusal to obey (defiance)

2) the failure or refusal to obey (disobedience)

3) not any; not a; used to express a strong feeling against, a refusal (no)

4) (an instance of) fighting; refusal to obey (rebellion)

5) an unkind refusal (of an offer of or request for help, friendship etc) (rebuff)

REFUSAL as in Wiktionary
REFUSAL as in Wikipedia