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History
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Meaning:
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a response to earlier action or activity; opposition to progress or change; (an instance of) a change in one substance caused by another

response

answer attitude backlash feedback feeling opinion reception reply return acknowledgment backfire boomerang comeback compensation counteraction counterbalance counterpoise echo hit kick kickback lip rebound receptivity reciprocation recoil reflection reflex rejoinder repercussion retort reverberation revulsion sass take vibes wisecrack back talk double-take knee-jerk reagency snappy comeback
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Cases of word usage

1) make a reaction with oxygen (oxygenate)

2) an answer (the usual word); reaction (response)

3) a strong feeling or reaction (vibe)

REACTION as in Wiktionary
REACTION as in Wikipedia