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History
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1) Acquired Immune Deficiency Syndrome (a very dangerous disease passed into the blood through sexual intercourse, syringe needles already used by an infected person etc) (AIDS)

2) (the wood of) a kind of tall tree growing in cold regions with leaves like needles (fir)

3) to make (an article of clothing etc) by looping wool etc on long needles (knit)

Synonyms
UK
US
Meaning:
anxiety

fear and uncertainty about the future

worry, tension

NEEDLES as in Wiktionary
NEEDLES as in Wikipedia