1) a difficult, irritating situation or condition (bind)
2) (of) an irritating substance (irritant)
3) a kind of disease with irritating sports (often round the waist) (shingles)
(of smell or taste) unpleasantly sharp; bitter
bitter, sour to taste
requiring much effort, strength, skill or ability
hard on someone; hard to do
unpleasant
offensive
very unpleasant; causing offence; used for, connected with, attacking
disrespectful, insulting; displeasing
causing worry, unhappiness, difficulty
bothersome, worrisome
causing tiredness, exhaustion, impatience etc
difficult, bothersome
not comfortable
painful, rough
(moving) in the opposite direction to the stream or current
hard on someone; hard to do
causing worry
troublesome
