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Meaning:
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at the outer end; at the end; of the highest degree, intensity etc

very great

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Cases of word usage

1) feeling of disgust for extreme hatred (abhorrence)

2) extreme hatred and disgust (abomination)

3) (an act of) extreme wickedness or cruelty (atrocity)

4) (an instance of) extreme cruelty (barbarity)

5) (of feelings etc) extreme (burning)

6) (of pain, suffering, bodily or mental) extreme (excruciating)

7) extreme point, end or limit (extremity)

8) a period of extremely cold weather; (to cause a substance) to become solid, especially as ice, because of extreme cold (freeze)

9) a part of a country bordering on another country; an extreme limit (frontier)

10) a state of extreme anger (fury)

EXTREME as in Wiktionary
EXTREME as in Wikipedia