(especially) the mental state of feeling or being different from other people, without friends

unfriendliness

(an instance of) defecting , e.g. to another political party (or its leader), to another religion etc

abandonment

the artificial process of removing waste products from the blood, e.g. when the kidneys are not working

being apart; break-up

an unfriendly feeling; hatred

antagonism, meanness

(an act of) separating or being separated or separate; an instance, period, of not being together

being apart; break-up