to make (a person) mad (because of worry, grief etc)

make crazy; confuse

to be a burden or difficulty to (a person, business, place etc) (and make action, movement difficult)

bother, burden

to break in on another person's affairs without right or invitation

meddle, intervene

to annoy (a person)

aggravate; rub the wrong way

to remove a load, cargo from (a lorry, ship etc); to get rid of (a person, thing, not wanted)

take off; empty

to cause (a person) to become troubled, anxious or uncertain

bother, upset